Sinuwave™ Photodisinfection for Invasive Fungal Sinusitis of Immunocompromised Patients

Acute invasive fungal sinusitis is the most aggressive form of fungal sinusitis. It is most commonly seen in immunocompromised patients and is the source of significant morbidity and mortality. Common causes of immunosuppression are diabetes, advanced AIDS  and neutropenia (low levels of white blood cells (neutrophils) in the blood). Patients with neutropenia include those with solid organ transplants, bone marrow transplants, leukemia, radiation therapy, chemotherapy, and any medication that affect bone marrow.

Ordinarily, fungi feed on dead organic matter, but not live human tissue. In the case of weakened immune defenses, however, fungi are able to attack and invade human tissue, hence the name “invasive fungal infections”.  With the patient having limited immune defenses, this invasive fungal infection can spread rapidly into the blood vessels, eye area, and central nervous system with devastating consequences. Within a few weeks, the disease results in vascular invasion and systemic dissemination. Roughly 12.5% of those with diagnosed fungal rhinosinusitis have invasive fungal rhinosinusitis- acute or chronic. Acute invasive fungal sinusitis is a rare condition with a high mortality rate when not recognized early and treated aggressively.

The key to successful outcomes is early detection and aggressive intervention. Invasive fungal rhinosinusitis is currently treated by aggressive medical (systemic antifungals) and surgical debridement to remove infected tissue in the sinuses using endoscopic sinus surgery. Sinuwave™ Photodisinfection, a non-invasive light activated therapy,  offers an effective alternative or adjunctive therapy for these vulnerable patients suffering from invasive fungal sinusitis. Photodisinfection has been proven to be safe over many years of experience in the dental and hospital acquired infection markets, and has proven to be highly effective at eliminating fungal organisms.

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