Posts tagged: chronic sinusitis symptoms

Sinuwave™ Photodisinfection for Invasive Fungal Sinusitis of Immunocompromised Patients

Acute invasive fungal sinusitis is the most aggressive form of fungal sinusitis. It is most commonly seen in immunocompromised patients and is the source of significant morbidity and mortality. Common causes of immunosuppression are diabetes, advanced AIDS  and neutropenia (low levels of white blood cells (neutrophils) in the blood). Patients with neutropenia include those with solid organ transplants, bone marrow transplants, leukemia, radiation therapy, chemotherapy, and any medication that affect bone marrow.

Ordinarily, fungi feed on dead organic matter, but not live human tissue. In the case of weakened immune defenses, however, fungi are able to attack and invade human tissue, hence the name “invasive fungal infections”.  With the patient having limited immune defenses, this invasive fungal infection can spread rapidly into the blood vessels, eye area, and central nervous system with devastating consequences. Within a few weeks, the disease results in vascular invasion and systemic dissemination. Roughly 12.5% of those with diagnosed fungal rhinosinusitis have invasive fungal rhinosinusitis- acute or chronic. Acute invasive fungal sinusitis is a rare condition with a high mortality rate when not recognized early and treated aggressively.

The key to successful outcomes is early detection and aggressive intervention. Invasive fungal rhinosinusitis is currently treated by aggressive medical (systemic antifungals) and surgical debridement to remove infected tissue in the sinuses using endoscopic sinus surgery. Sinuwave™ Photodisinfection, a non-invasive light activated therapy,  offers an effective alternative or adjunctive therapy for these vulnerable patients suffering from invasive fungal sinusitis. Photodisinfection has been proven to be safe over many years of experience in the dental and hospital acquired infection markets, and has proven to be highly effective at eliminating fungal organisms.

Sinuwave Photodisinfection System to Augment Current Endoscopic Sinus Surgery and Balloon Sinuplasty Procedures

When patients with Chronic Rhinosinusitis (CRS) are not responsive to medical therapy, they may be candidates for an endoscopic procedure that includes endoscopic sinus surgery, balloon sinuplasty, or a hybrid of a combination of these two. Endoscopic sinus surgery involves identifying and removing blockages of the sinus passages using high definition cameras, monitors, and a host of tiny articulating instruments. The operation is commonly performed with a general anesthetic, with instruments that access the sinuses through the nose, and only involving incisions of the face for the most severe of conditions.

The combination of endoscopic procedures and Sinuwave may help improve patient outcomes with minimal tissue removal. Balloon sinuplasty is also a surgical intervention but operates on an entirely different principle. It uses a balloon on a wire catheter to attempt to dilate the sinus passageways, widening the walls of the sinus passageway with the goal of restoring normal drainage without permanently damaging the sinus lining. Side-effects such as scarring of sinus tissue is unlikely using sinuplasty, unlike with surgery, but both of these current procedures are unable to address the underlying cause, only the blockages.

Hybrid procedures, which are becoming more popular as a result of improved patient outcomes, deploy both surgery and sinuplasty. Whether hybrid, surgery or sinuplasty, patient results can be further improved by the addition of Sinuwave™ Photodisinfection technology to remove the fungal and bacterial biofilm infections as well as their virulence factors within the sinuses, in addition to inactivating the host inflammatory cytokines. This 3 prong advantage of Photodisinfection enables ENT’s the ability to clear out the source of infection, and not just remove the blockage of the sinus passages. By clearing out the sinus cavities with several logs of kill, the body has a greater chance of returning to better health and avoid long term pain.

The Advantages of Sinuwave for Refractory Chronic Rhinosinusitis

Sinusitis is a disease in which the sinus cavities around the nasal passages become inflamed and swollen. When symptoms last for longer than12 weeks, the patient is described as suffering from chronic rhinosinusitis (CRS).  Patients typically first seek medical therapy to alleviate their symptoms as well as trying to address the cause. However, 20% of patients are unresponsive to any of the medicines and continue to suffer from the debilitating symptoms associated with CRS.

There are roughly 22 million office visits and 500,000 emergency department visits in the United States alone relating to CRS, indicating that it is a major health concern. The treatment regimen usually consists of the prescription of broad spectrum antibiotics, corticosteroids, and saline nasal irrigation. This disease most commonly affects young and middle aged adults, but may affect other demographics as well. Common symptoms include nasal congestion, throbbing facial pain, fever, headaches, difficulty sleeping and sensations of swelling around the eyes and face.

Sinuwave™ Photodisinfection System offers a unique method of treatment which has several distinct advantages over both medical and surgical CRS treatments. Photodisinfection is a minimally invasive approach to eliminating the pathogens and inflammatory host response involved in the disease process.  Photodisinfection is a 2 step process involving the application of a photosensitizer which is then activated by non-thermal laser light generating singlet oxygen based molecules, or free radicals that are lethal to fungal spores, bacterial biofilms and their virulence factors while not harming human tissue.

The major advantages of Sinuwave™ Photodisinfection for CRS patients are:

* pain-free procedure not requiring anesthesia

* immediate patient relief,

* no antibiotics or developed resistances,

* no removal of tissues are involved,

* no patient compliance requirements

* ease of use

Sniff, slice or swallow? All guesses are good when it comes to chronic sinusitis

We’ve all had colds that seem never-ending, and wondered if maybe, just maybe, we would one day be able to breathe without sounding like a foghorn.

Well for some people, that kind of nasal hell is just another day in the life.

Sinusitis causes swelling in the sinuses and nose, preventing the accumulated mucus from being drained out. The result is pain and pressure around the eyes, sore teeth, and constant headaches. People who suffer from chronic sinusitis go through that for days or even months at a time.

Physicians have recently come around to the idea that chronic sinusitis is an inflammation-related condition, rather than an infection to be treated with antibiotics. Treatment ideology has also shifted. Rather than relying on pills and other external treatments, doctors increasingly believe in getting medicine directly inside the sinuses, up close and personal.

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Let’s Clear Things Up: Chronic Sinusitis

You know that feeling, when your nose is so stuffed that you feel like your head is filled with wet cotton, your thoughts seem foggy and every breath is a burning struggle? Well, multiply that by ten, and you get chronic sinusitis.

What causes this case of the perpetual sniffles? Well that’s the big question.

An article by Inofei Chen, “When Sinus Problems Won’t Go Away,” published in The New York Times in 2011, explored the different theories explaining chronic sinusitis that have emerged over the last couple of years.

Clarification: sinusitis does not equal chronic sinusitis. Sinusitis is a short-term condition that lasts for a couple of weeks, and is usually caused by an infection.

But in millions of cases, boring old sinusitis can become recurrent, and drag on for weeks, months, even years – chronic sinusitis.  For a full list of symptoms, click here.

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How Do I Know I Have Chronic Sinusitis?

As a first year medical student, cancer and HIV/AIDS are two common illnesses that I without a doubt will encounter in my line of work. However, not many people know about chronic rhinosinusitis, or simply known as chronic sinusitis, which also affects many people. Each year, 37 million Americans are faced with combating a case of sinusitis, the fifth most common disease treated with antibiotics [1,2].

What exactly is chronic sinusitis? It is an inflammation of the tissue in our sinuses, the cavities around our eyes, nose, cheeks, and forehead. Usually they are full of air but due to various causes these spaces become filled with viruses, bacteria, and fungi.

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More Than Just A Headache: The Under Recognized Pain and Disability of Chronic Sinusitis

Few words can fully describe the throbbing pain, pressure, and congestion of a chronic sinus infection.  Falling somewhere between a toothache, a migraine headache, and the flu, sinusitis not only impacts quality of life, but also puts sufferers at risk of developing more serious complications including blood clots and aneurysms, due to its close proximity to the brain and major blood vessels.  For the most part though, it’s more synonymous with missed work, painful headaches, and overall misery than with severe illness.

For the majority of sinusitis sufferers, impaired mucous clearance is where the trouble begins.  Anything from a simple cold or allergy to structural defects, such as badly formed nasal cartilage or benign nasal growths have the ability to affect sinus drainage.  Poor drainage, in turn, leads to a secondary bacterial infection—and the associated green, infected nasal discharge noted among sinusitis sufferers. While most people manage to kick sinusitis with a single course of antibiotics and little effort, for others it’s the beginning of a nightmare that lasts for months, if not years.  Read more »

Sinuwave Presented at Leading Photodynamic Symposium

We’re pleased to announce our participation as a presenter at the  9th International Symposium  “Photodynamic Therapy and Photodiagnosis in Clinical Practice”  held at  the University of Padova, Brixen, South Tyrol, Italy October 16-20th, 2012.

The symposium, headed by Prof. Giulio Jori (University of Padova), Prof. Herwig Kostron, the Current President of the International Photodynamic Association (University of Innsbruck), and Prof. Heinrich Walt (University of Zürich), is a collaboration with the 4th International Meeting of the European Platform for Photodynamic Medicine (EPPM). Spanning the full range of basic research to pre-clinical and clinical studies in the the field of Photodiagnosis and Photodynamic Therapy, this symposium is an annual gathering of international PDT leaders.

Dr. Merrill Biel, our Chief Medical Officer, spoke on the clinical merits of Sinuwave for the treatment of chronic sinusitis, as well as the product development work done to date.  It is estimated that there are well over 7 million chronic sinusitis sufferers in the US alone who suffer from chronic pain, drainage, and headache. It is our goal to provide them with an immediate, safe, and effective therapy that will relief them from their pain and suffering.

Sinuwave – A Non-Antibiotic Approach To Treating Chronic Sinusitis

Chronic sinusitis is a debilitating disease that affects more than 7 million people in the U.S. Typically, each episode of chronic sinusitis can last more than 12 weeks and occur 2-4 times annually.  Symptoms of chronic sinusitis include inflammation of the sinus tissue, build up of mucus and pus inside the sinus cavities, nasal discharge, difficulty breathing, throbbing facial pain, headaches, and swelling of the eyes and nose.

Inflammation and swelling of the sinus tissues, due to infections or allergies, can cause mucus to remain trapped in the sinus cavities.  This mucus buildup becomes a breeding ground for more bacteria to grow and produce virulence factors that further contribute to inflammation. In what seems to be a vicious circle of increasing bacterial growth and inflammation, a rapid approach to killing bugs and inactivating inflammatory markers is desperately needed.

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