Posts tagged: Sinuwave

Photodisinfection for Refractory Chronic Rhinosinusitis Patients: A much needed advance for an under-served patient population

Chronic rhinosinusitis (CRS) is one of the most common chronic conditions in the United States. There is a significant subpopulation of CRS patients who remain resistant to cure despite rigorous treatment regimens including surgery, allergy therapy, and prolonged antibiotic therapy. This refractory patient population is thought to exceed 500,000 in the US.

Photodisinfection, also known as antimicrobial photodynamic therapy (aPDT), is a noninvasive, non-antibiotic broad spectrum antimicrobial treatment that can improve outcomes for this under-served patient population by reducing inflammation of sinus tissue and eliminating biofilm in the sinuses. Patients  suffering from refractory Chronic Rhinosinusitis are likely to be infected by super-antigen producing bacterial such as Staph aureus and Pseudomonas aeruginosa. Photodisinfection has been proven to be highly effective at targeting these two pathogens and inactivating inflammatory cytokines.

Sinuwave Presented at Leading Photodynamic Symposium

We’re pleased to announce our participation as a presenter at the  9th International Symposium  “Photodynamic Therapy and Photodiagnosis in Clinical Practice”  held at  the University of Padova, Brixen, South Tyrol, Italy October 16-20th, 2012.

The symposium, headed by Prof. Giulio Jori (University of Padova), Prof. Herwig Kostron, the Current President of the International Photodynamic Association (University of Innsbruck), and Prof. Heinrich Walt (University of Zürich), is a collaboration with the 4th International Meeting of the European Platform for Photodynamic Medicine (EPPM). Spanning the full range of basic research to pre-clinical and clinical studies in the the field of Photodiagnosis and Photodynamic Therapy, this symposium is an annual gathering of international PDT leaders.

Dr. Merrill Biel, our Chief Medical Officer, spoke on the clinical merits of Sinuwave for the treatment of chronic sinusitis, as well as the product development work done to date.  It is estimated that there are well over 7 million chronic sinusitis sufferers in the US alone who suffer from chronic pain, drainage, and headache. It is our goal to provide them with an immediate, safe, and effective therapy that will relief them from their pain and suffering.

Sinuwave – A Non-Antibiotic Approach To Treating Chronic Sinusitis

Chronic sinusitis is a debilitating disease that affects more than 7 million people in the U.S. Typically, each episode of chronic sinusitis can last more than 12 weeks and occur 2-4 times annually.  Symptoms of chronic sinusitis include inflammation of the sinus tissue, build up of mucus and pus inside the sinus cavities, nasal discharge, difficulty breathing, throbbing facial pain, headaches, and swelling of the eyes and nose.

Inflammation and swelling of the sinus tissues, due to infections or allergies, can cause mucus to remain trapped in the sinus cavities.  This mucus buildup becomes a breeding ground for more bacteria to grow and produce virulence factors that further contribute to inflammation. In what seems to be a vicious circle of increasing bacterial growth and inflammation, a rapid approach to killing bugs and inactivating inflammatory markers is desperately needed.

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